Intrinsic T cell defects in systemic autoimmunity
PL Kong, JM Odegard, F Bouzahzah… - Annals of the New …, 2003 - Wiley Online Library
Annals of the New York Academy of Sciences, 2003•Wiley Online Library
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T
cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T
cells from individuals with lupus are abnormal. Here, we review the known T cell defects in
lupus and their possible biochemical nature, genetic causes, and significance for lupus
pathogenesis.
cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T
cells from individuals with lupus are abnormal. Here, we review the known T cell defects in
lupus and their possible biochemical nature, genetic causes, and significance for lupus
pathogenesis.
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T cells from individuals with lupus are abnormal. Here, we review the known T cell defects in lupus and their possible biochemical nature, genetic causes, and significance for lupus pathogenesis.
Wiley Online Library