[HTML][HTML] Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis
C Surmann-Schmitt, U Dietz, T Kireva, N Adam… - Journal of Biological …, 2008 - ASBMB
Here we report on the structure, expression, and function of a novel cartilage-specific gene
coding for a 17-kDa small, highly charged, and secreted protein that we termed Ucma
(unique cartilage matrix-associated protein). The protein is processed by a furin-like
protease into an N-terminal peptide of 37 amino acids and a C-terminal fragment (Ucma-C)
of 74 amino acids. Ucma is highly conserved between mouse, rat, human, dog, clawed frog,
and zebrafish, but has no homology to other known proteins. Remarkable are 1-2 tyrosine …
coding for a 17-kDa small, highly charged, and secreted protein that we termed Ucma
(unique cartilage matrix-associated protein). The protein is processed by a furin-like
protease into an N-terminal peptide of 37 amino acids and a C-terminal fragment (Ucma-C)
of 74 amino acids. Ucma is highly conserved between mouse, rat, human, dog, clawed frog,
and zebrafish, but has no homology to other known proteins. Remarkable are 1-2 tyrosine …
