Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins
M Abdelrahim, S Liu, S Safe - Journal of Biological Chemistry, 2005 - ASBMB
Endoplasmic reticulum (ER) stress plays a critical role in multiple diseases, and
pharmacologically active drugs can induce cell death through ER stress pathways. Stress-
induced genes are activated through assembly of transcription factors on ER stress
response elements (ERSEs) in target gene promoters. Gel mobility shift and chromatin
immunoprecipitation assays have confirmed interactions of NF-Y and YY1 with the distal
motifs of the tripartite ERSE from the glucose-related protein 78 (GRP78) gene promoter …
pharmacologically active drugs can induce cell death through ER stress pathways. Stress-
induced genes are activated through assembly of transcription factors on ER stress
response elements (ERSEs) in target gene promoters. Gel mobility shift and chromatin
immunoprecipitation assays have confirmed interactions of NF-Y and YY1 with the distal
motifs of the tripartite ERSE from the glucose-related protein 78 (GRP78) gene promoter …
